CNR - Institute of Neuroscience CNR
Institute of Neuroscience
 

Project

Evaluation of Obstructive Lung disease and Osteoporosis (EOLO Study)

Introduction

The natural course of chronic obstructive pulmonary disease (COPD) is complicated by the development of systemic consequences, such as exercise intolerance and sarcopenia, leading to progressive physical disability and loss of autonomy. The mechanisms by which these complications develop are unclear and probably they are multifactorial, including systemic inflammation, inactivity, malnutrition, and pharmacological treatments. Osteoporosis is now considered one of the worst systemic complications of COPD, because the associated fractures, in particular vertebral fractures, can worsen the COPD morbidity and increase mortality.

Although previous reports suggest that as many as 60% of patients with obstructive airways disease have osteoporosis, several methodological problems, including small samples, different disease duration and severity do not allow the generalizability of the results.

Methods

We used data from the EOLO (Evaluation of Obstructive Lung disease and Osteoporosis) Study to determine whether COPD is an important risk factor for osteoporosis, independently from factors often associated to both conditions.

 

Conclusions

  1. The prevalence rates of osteopenia and osteoporosis in COPD patients are higher than in the general population of the same age and sex.
  2. The frequency of osteoporosis is associated to the COPD severity, even after adjusting for age, sex, BMI, smoking and GCs use.
  3. Sex-specific multivariate analyses did not show differences between men and women in the association of predictors and outcomes.
  4. This study confirms that COPD patients are at higher risk of osteoporotic fractures compared to the general population.

Publications

  • Maggi S, Siviero P, Gonnelli S, Schiraldi C, Malavolta N, Nuti R, Crepaldi G, (0) Osteoporosis risk in patients with chronic obstructive pulmonary disease: the EOLO study. 12:345-52.
  • Nuti R, Siviero P, Maggi S, Guglielmi G, Caffarelli C, Crepaldi G, Gonnelli S (2009) Vertebral fractures in patients with chronic obstructive pulmonary disease: the EOLO Study. 20:989-98.

Grants

The EOLO Study is supported by an unrestricted grant from P&G

Collaborations

  • Angeli A, De Rose V, Orbassano, Cravero M, Fantino S, Isaia G, Baldi S, Torino
  • Cisari C, Ronco M, Novara
  • Rocchetta PA, Polla B, Alessandria
  • Mondavio M, Ferraro G, Acqui Terme (AL)
  • Bianchi G, Bonaria M, Arenzano (GE)
  • Versace F, Vacca N, Savona
  • Calitro M, Iaffaldano A, Canosa di Puglia (BA)
  • Muratore M, Mandurino L, S. Cesareo di Lecce (LE)
  • Maugeri D, Distefano S, Fiore CE, Di Maria G, Catania
  • Frisina N, Girbino G, Messina
  • Rossetto S, Rossetto G, Piazza Armerina (EN)
  • Pedrazzoni M, Cuomo A, Parma
  • Trotta Francesco, Potena A, Ferrara
  • Biondi M, Fiorentini F, Forlì
  • Malavolta N, Fagiani A, Bologna
  • Del Forno L, Colaneri A, Vasto (CH)
  • De Felice A, De Matthaeis G, Lanciano (CH)
  • Di Matteo L, Cortese G, Pescara
  • Mancini G, Tubaldi A, Macerata
  • Pozone M, Fiore Donati A, L'Aquila
  • Sfrappini M, Olori G, S. Benedetto del Tronto (AP)
  • Silveri F, Subiaco S, Jesi (AN)
  • Latte VM, Ricciardi C, Noverino L, Tallarico L, Del Puente A, Zedda A, Borg MJ, Longobardi U, Napoli
  • Cerqua R, Califano M, San Felice a Cancello (CE)
  • Aversa A, Battaglia E, Santi I, Caratozzolo O, Milano
  • Tenca P, Davoli C, Bosio G, Cremona
  • Cavaiani P, Alessandrini A, Abbiategrasso (MI)
  • Rondena M, Grechi A, Legnano (MI)
  • Galimberti G, Ciccarelli M, Rozzano (MI)
  • Giustina A, Cantucci C, Brescia
  • Giannini S, Zuin R, Padova
  • Bertoldo F, Ferrari M, Verona
  • Adami S, Cipriani A, Valeggio (VR)
  • Bortolotti R, Sella D, Trento
  • Schinella D, Mazza F, Pordenone
  • Di Virgilio R, Santelli G, Treviso
  • Tartarelli G, Vincenti R, Massa
  • Bertolucci D, Torrini A, Lido di Camaiore (LU)
  • Di Munno O, Paggiaro P, Pisa
  • Sabadini L, Naldi M, Arezzo
  • Brandi ML, Pistoleri M, Firenze
  • Nuti R, Frediani B, Rottoli P, Siena
  • Cecchetti R, Faloppa C, Pontedera (PI)
  • Bancheri C, Trequatrini T, Falaschi P, Mariotta S, Roma
  • Napoletano C, Dominaci M, Latina

 

no PI photo

Paola Siviero

Contact information

email  E-mail

email  049 8218899

Participating staff

Stefania Maggi

Marianna Noale

G. Romanato