CNR - Institute of Neuroscience CNR
Institute of Neuroscience
 

Project

Clinical Neurophysiology of Vision

 

The signal structure of the responses to equiluminant chromatic and achromatic (contrast) stimuli was studied in normal volunteers and patients with mild to moderate idiopathic Parkinson's disease. Visual stimuli were full-field (14 x 16 deg) achromatic or equiluminant (red-green or blue-yellow) sinusoidal gratings at 2c/deg and 90% contrast presented in onset-offset mode. The signal was processed offline by DFT and factor analysis was performed in the frequency domain. The conventional VEPs to chromatic onset stimuli showed a monophasic negative wave, while the response to offset stimuli was comparable in shape to the on-/offset achromatic responses; latencies were longer and amplitudes higher than those of responses to contrast stimulation. In patients, latencies were longer than in controls after achromatic and (to a lesser extent) red-green stimulations, but not after blue-yellow stimulation; amplitudes were comparable in all stimulus conditions. In healthy subjects, two non-overlapping factors accounted for the approximately 2-30.0 Hz and approximately 25.0-50.0 Hz signal components (representative of the low-frequency VEP and gamma oscillatory responses, respectively); the frequency of the approximately 25.0-50.0 Hz factor was lower after color than after contrast stimulation. The same factor structure was identified in patients, but the peak frequency of the factor on gamma activity was higher than in controls and did not vary with color-opponent stimulation. These observations indicate that stimulus-related gamma activity originates in cortex irrespective of the activated (magno-, parvo-, or konio-cellular) visual pathway, consistent with the suggested role in the phase coding of neuronal activities. Some dopaminergic modulation of gamma activity is conceivable.

Major scientific contributions:

  • Color vision and related alteration in the neurological pathology
  • Visula sistem such analizer of face,sex;influence of pheromones with psicophisiological and electrophisiological technique
  • Electromiographic technique in evaluation of neuromuscolar, disease
  • Use of Evoked potential (ERPs) in the study of cognitive functions of dementia and of Mild Cognitive Impairment
  • Electrophisiological technique use in coma state and in cerebral death
  • Electrophisiological technique in intraoperative monitoring (MIO)
  • Study of vegetative neuropathy by the study of sympathetic nervous sistem RSC)

Publications

  • Cosottini M, Pesaresi I, Maritato P, Belmonte G, Taddei A, Sartucci F, Mascalchi M, Murri L (2010) EEG topography-specific BOLD changes: a continuous EEG-fMRI study in a patient with focal epilepsy. Magn Reson Imaging 28:388-93.
  • Truini A, Panuccio G, Galeotti F, Maluccio MR, Sartucci F, Avoli M, Cruccu G (2010) Laser-evoked potentials as a tool for assessing the efficacy of antinociceptive drugs. Eur J Pain 14:222-5.
  • Sannita WG, Carozzo S, Orsini P, Domenici L, Porciatti V, Fioretto M, Garbarino S, Sartucci F (2009) 'Gamma' band oscillatory response to chromatic stimuli in volunteers and patients with idiopathic Parkinson's disease. Vision Res. 49:726-34.
  • Borghetti D, Sartucci F, Petacchi E, Guzzetta A, Piras MF, Murri L, Cioni G (2008) Transcranial magnetic stimulation mapping: a model based on spline interpolation. Brain Res. Bull. 77:143-8.
  • Della Nave R, Ginestroni A, Tessa C, Cosottini M, Giannelli M, Salvatore E, Sartucci F, De Michele G, Dotti MT, Piacentini S, Mascalchi M (2008) Brain structural damage in spinocerebellar ataxia type 2. A voxel-based morphometry study. Mov. Disord. 23:899-903.
  • Antonucci F, Di Garbo A, Novelli E, Manno I, Sartucci F, Bozzi Y, Caleo M (2008) Botulinum neurotoxin E (BoNT/E) reduces CA1 neuron loss and granule cell dispersion, with no effects on chronic seizures, in a mouse model of temporal lobe epilepsy. Exp. Neurol. 210:388-401.
  • Sartucci F, Tovani S, Murri L, Sagliocco L (2007) Motor and somatosensory evoked potentials in Autosomal Dominant Hereditary Spastic Paraparesis (ADHSP) linked to chromosome 2p, SPG4. Brain Res. Bull. 74:243-9.
  • Sartucci F, Maritato P, Moscato G, Orlandi G, Calabrese R, Domenici GL, Murri L (2007) Motor unit number estimation (mune) as a quantitative measure of disease progression and motor unit reorganization in amyotrophic lateral sclerosis. Int. J. Neurosci. 117:1229-36.
  • Borghetti D, Bruni A, Fabbrini M, Murri L, Sartucci F (2007) A low-cost interface for control of computer functions by means of eye movements. Comput. Biol. Med. 37:1765-70.
  • Borghetti D, Pizzanelli C, Maritato P, Fabbrini M, Jensen S, Iudice A, Murri L, Sartucci F (2007) Mismatch negativity analysis in drug-resistant epileptic patients implanted with vagus nerve stimulator. Brain Res. Bull. 73:81-5.

Grants

Progetti di Ricerca di interesse nazionale, finanziati MIUR

Cofinanziamento 2003, area 06 - Scienze Mediche: "Effetti dei feromoni sull'attività elettrica cerebrale correlata all'identificazione del sesso dei volti (Coordinatore scientifico: prof. Jannini Emmanuele Angelo Francesco). Fa parte dell'unità di ricerca di Pisa (Responsabile Scientifico prof. Luigi Murri) di tale programma di ricerca Nazionale

Cofinanziamento 2006, area 06 - Scienze Mediche: Geni dell'angiogenesi indotti da ipossia: fattori di suscettibilità nella Sclerosi Laterale Amiotrofica ? (Coordinatore scientifico prof. Giannini Fabio Università degli Studi di Siena), come Responsabile Scientifico di Unità di Ricerca di Pisa

Progetti di Ricerca di interesse nazionale, finanziati da Privati

Fondazione cassa di Risparmio di Lucca, agosto 2004: finanziamento per progetto di ricerca sui meccanismi e fattori di regolazione processi neurodegenerativi nella malattia di Alzheimer

Fondazione Cassa di Risparmio di Pisa, Settembre 2005: Studio integrato su modelli animali e pazienti al fine di produrre un protocollo per la diagnosi precoce di malattia di Alzheimer

Collaborations

  • Lamberto Maffei
  • Vittorio Porciatti, Bascom Palmer Eye Institute, University of Miami, School of Medicine, Miami, USA.
  • Alessandro Cellerino, Scuola Normale Superiore di Pisa ed Istituto di Neuroscienze del CNR, Pisa.
  • Eleuterio Ferrannini, Dipartimento di Medicina Interna, Facoltà di Medicina e Chirurgia, Università di Pisa.
  • Umberto Barcaro e Ovidio Salvetti, ISTI-CNR, Pisa.
  • Enrico Macchia, Domenico Canale, Dipartimento di Endocrinologia e Metabolismo, Ortopedia e Traumatologia, Medicina del Lavoro, Facoltà di Medicina e Chirurgia, Università di Pisa.
  • Franco Filipponi, Dipartimento di Oncologia, dei Trapianti e delle Nuove Tecnologie in Medicina.
  • Yuri Bozzi, Istituto di Neuroscienze del CNR, Pisa.
  • Matteo Caleo
  • Luciano Domenici

 

PI photo

Ferdinando Sartucci

Contact information

email  E-mail

email  +39 050 996 767

Participating staff

Tommaso Bocci
M.D.

Elisa Giorli
M.D.

Michelangelo Bartolotta
Technician

Michela Santin
Secretary

Orietta Ricci
Secretary